The Potential Role of hsa_circ_0005505 in the Rupture of Human Intracranial Aneurysm

Objective: Recently, abundant number of studies have revealed many functions circular RNAs in multiple diseases, however, the role RNA rupture human intracranial aneurysm is still unknown. This study aims to explore potential aneurysms. Methods: The differentially expressed between un-ruptured aneurysms ( n = 5) and ruptured were analyzed with Arraystar circRNAs microarray. Quantitative real-time PCR (qPCR) was used verify results circRNA assessed vitro . MTT assay, CCK-8 Caspase3/7 assay cell apoptosis Celigo wound healing conducted evaluate relationship Results: A total 13,175 genes detected. Among them 63 upregulated 54 downregulated significantly compared p < 0.05 Fold Change > 1.5). Five selected for further (hsa_circ_0001947, hsa_circ_0043001, hsa_circ_0064557, hsa_circ_0058514, hsa_circ_0005505). qPCR showed only hsa_circ_0005505 0.05). expression higher tissues. And our data that hsa_circRNA_005505 promotes proliferation, migration suppresses vascular smooth muscle cell. Conclusion: an important cell, indicated may associate pathological process